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DHL stimulated the decreased expression of CD206 and TREM-2, as the markers of the endometriosis-associated macrophage M2 phenotype, as well as the decreased expression of MCP-1 and M2-related molecules (IL-10, VEGF, MMP-2 and MMP-9)

This action of CHAC1 aligns with its regulation by transcription factors ATF4 and ATF3, suggesting a tightly controlled mechanism whereby CHAC1 contributes to the cellular apoptosis process, particularly in stress responses ( 4.5 Ferroptosis Ferroptosis is a regulated form of cell death characterized by the accumulation of lipid peroxides, particularly in membrane phospholipids, which occurs when the cellular antioxidant defense is insufficient

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